Urinary beta-2 microglobulin and alpha-1 microglobulin are useful screening markers for tenofovir-induced kidney tubulopathy in patients with HIV-1 infection: a …
M Takano, J Tanuma, K Tsukada, K Teruya… - Journal of infection and …, 2013 - Elsevier
Kidney tubulopathy is a well-known adverse event of antiretroviral agent tenofovir. A cross-
sectional study was conducted to compare the diagnostic accuracy of five tubular markers,
with a collection of abnormalities in these markers as the reference standard. The study
subjects were patients with HIV-1 infection on ritonavir-boosted darunavir plus
tenofovir/emtricitabine with suppressed viral load. Kidney tubular dysfunction (KTD) was
predefined as the presence of at least three abnormalities in the following five parameters …
sectional study was conducted to compare the diagnostic accuracy of five tubular markers,
with a collection of abnormalities in these markers as the reference standard. The study
subjects were patients with HIV-1 infection on ritonavir-boosted darunavir plus
tenofovir/emtricitabine with suppressed viral load. Kidney tubular dysfunction (KTD) was
predefined as the presence of at least three abnormalities in the following five parameters …
