[HTML][HTML] Severely altered cholesterol homeostasis in macrophages lacking apoE and SR-BI
PG Yancey, JW Gray, Y Hong, EE Griffin, BE Cox… - Journal of lipid …, 2007 - ASBMB
Mice deficient in scavenger receptor class B type I (SR-BI) and apolipoprotein E
(apoE)[double knockout (DKO) mice] develop dyslipidemia, accelerated atherosclerosis,
and myocardial infarction, and die prematurely. We examined effects of apoE and SR-BI
deficiency on macrophage cholesterol homeostasis. DKO macrophages had increased total
cholesterol (TC) stores (220–380 μg/mg protein) compared with apoE−/− cells (40 μg/mg),
showed significant lysosomal lipid engorgement, and increased their TC by 34% after …
(apoE)[double knockout (DKO) mice] develop dyslipidemia, accelerated atherosclerosis,
and myocardial infarction, and die prematurely. We examined effects of apoE and SR-BI
deficiency on macrophage cholesterol homeostasis. DKO macrophages had increased total
cholesterol (TC) stores (220–380 μg/mg protein) compared with apoE−/− cells (40 μg/mg),
showed significant lysosomal lipid engorgement, and increased their TC by 34% after …
