Hypoxia-induced hyperpermeability in brain microvessel endothelial cells involves VEGF-mediated changes in the expression of zonula occludens-1
S Fischer, M Wobben, HH Marti, D Renz… - Microvascular …, 2002 - Elsevier
In vivo, hypoxia is known to damage the blood–brain barrier (BBB) leading to the
development of vasogenic brain edema. Primary cultures of porcine brain derived
microvascular endothelial cells were used as an in vitro BBB model to evaluate the
mechanisms by which hypoxia regulates paracellular permeability. Paracellular passage
across endothelial cell monolayers is regulated by specialized intercellular structures like
the tight junctions (TJ). Zonula occludens-1 (ZO-1), a protein of the TJ, lines the cytoplasmic …
development of vasogenic brain edema. Primary cultures of porcine brain derived
microvascular endothelial cells were used as an in vitro BBB model to evaluate the
mechanisms by which hypoxia regulates paracellular permeability. Paracellular passage
across endothelial cell monolayers is regulated by specialized intercellular structures like
the tight junctions (TJ). Zonula occludens-1 (ZO-1), a protein of the TJ, lines the cytoplasmic …
