c-Cbl, a ubiquitin E3 ligase that targets active β-catenin: a novel layer of Wnt signaling regulation
V Chitalia, S Shivanna, J Martorell, R Meyer… - Journal of Biological …, 2013 - ASBMB
Regulation of transcriptionally active nuclear β-catenin during the Wnt-on phase is crucial to
ensure controlled induction of Wnt target genes. Several ubiquitin E3 ligases are known to
regulate cytosolic β-catenin during the Wnt-off phase, but little is known about the fate of
active nuclear β-catenin in the Wnt-on phase. We now describe ubiquitination of active β-
catenin in the Wnt-on phase by a RING finger ubiquitin E3 ligase, Casitas B-lineage
lymphoma (c-Cbl) in endothelial cells. c-Cbl binds preferentially to nuclearly active β-catenin …
ensure controlled induction of Wnt target genes. Several ubiquitin E3 ligases are known to
regulate cytosolic β-catenin during the Wnt-off phase, but little is known about the fate of
active nuclear β-catenin in the Wnt-on phase. We now describe ubiquitination of active β-
catenin in the Wnt-on phase by a RING finger ubiquitin E3 ligase, Casitas B-lineage
lymphoma (c-Cbl) in endothelial cells. c-Cbl binds preferentially to nuclearly active β-catenin …
