Novel risk loci in tinnitus and causal inference with neuropsychiatric disorders among adults of European ancestry
RE Clifford, AX Maihofer, MB Stein… - … –Head & Neck …, 2020 - jamanetwork.com
Importance Tinnitus affects at least 16 million US adults, but its pathophysiology is
complicated, and treatment options remain limited. A heritable component has been
identified in family and twin studies; however, no large-scale genome-wide association
studies (GWAS) have been accomplished. Objective To identify genetic risk loci associated
with tinnitus, determine genetic correlations, and infer possible relationships of tinnitus with
hearing loss and neuropsychiatric disorders and traits. Design, Setting, and Participants A …
complicated, and treatment options remain limited. A heritable component has been
identified in family and twin studies; however, no large-scale genome-wide association
studies (GWAS) have been accomplished. Objective To identify genetic risk loci associated
with tinnitus, determine genetic correlations, and infer possible relationships of tinnitus with
hearing loss and neuropsychiatric disorders and traits. Design, Setting, and Participants A …