The role of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) in kidney disease
SY Li, K Susztak - Seminars in nephrology, 2018 - Elsevier
Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a key transcriptional
regulator of mitochondrial biogenesis and function. Several recent studies have evaluated
the role of PGC-1α in various renal cell types in healthy and disease conditions. Renal
tubule cells mostly depend on mitochondrial fatty acid oxidation for energy generation. A
decrease in PGC-1α expression and fatty acid oxidation is commonly observed in patient
samples and mouse models with acute and chronic kidney disease. Conversely, increasing …
regulator of mitochondrial biogenesis and function. Several recent studies have evaluated
the role of PGC-1α in various renal cell types in healthy and disease conditions. Renal
tubule cells mostly depend on mitochondrial fatty acid oxidation for energy generation. A
decrease in PGC-1α expression and fatty acid oxidation is commonly observed in patient
samples and mouse models with acute and chronic kidney disease. Conversely, increasing …
