[HTML][HTML] Specific expression and regulation of hepassocin in the liver and down-regulation of the correlation of HNF1α with decreased levels of hepassocin in human …
HT Yu, M Yu, CY Li, YQ Zhan, WX Xu, YH Li… - Journal of biological …, 2009 - ASBMB
Hepassocin (HPS), is a liver-specific gene with mitogenic activity on isolated hepatocytes. It
is up-regulated following partial hepatectomy and down-regulated frequently in
heptocellular carcinoma (HCC). However, very little is known about the HPS transcription
regulation mechanism. In this study, we identified HNF1α (hepatocyte nuclear factor-1α) as
an important liver-specific cis-acting element for HPS using in vivo luciferase assays.
Deletion of the HNF1 binding site not only led to a complete loss of HPS promoter activity in …
is up-regulated following partial hepatectomy and down-regulated frequently in
heptocellular carcinoma (HCC). However, very little is known about the HPS transcription
regulation mechanism. In this study, we identified HNF1α (hepatocyte nuclear factor-1α) as
an important liver-specific cis-acting element for HPS using in vivo luciferase assays.
Deletion of the HNF1 binding site not only led to a complete loss of HPS promoter activity in …
