[HTML][HTML] The targeting of cystinosin to the lysosomal membrane requires a tyrosine-based signal and a novel sorting motif
S Cherqui, V Kalatzis, G Trugnan, C Antignac - Journal of Biological …, 2001 - ASBMB
Cystinosis is a lysosomal transport disorder characterized by an accumulation of intra-
lysosomal cystine. Biochemical studies showed that the lysosomal cystine transporter was
distinct from the plasma membrane cystine transporters and that it exclusively transported
cystine. The gene underlying cystinosis, CTNS, encodes a predicted seven-transmembrane
domain protein called cystinosin, which is highly glycosylated at the N-terminal end and
carries a GY-XX-Φ (where Φ is a hydrophobic residue) lysosomal-targeting motif in its …
lysosomal cystine. Biochemical studies showed that the lysosomal cystine transporter was
distinct from the plasma membrane cystine transporters and that it exclusively transported
cystine. The gene underlying cystinosis, CTNS, encodes a predicted seven-transmembrane
domain protein called cystinosin, which is highly glycosylated at the N-terminal end and
carries a GY-XX-Φ (where Φ is a hydrophobic residue) lysosomal-targeting motif in its …