[HTML][HTML] Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum
M Kikkert, R Doolman, M Dai, R Avner… - Journal of Biological …, 2004 - ASBMB
The ubiquitin system plays an important role in endoplasmic reticulum (ER)-associated
degradation of proteins that are misfolded, that fail to associate with their oligomerization
partners, or whose levels are metabolically regulated. E3 ubiquitin ligases are key enzymes
in the ubiquitination process as they recognize the substrate and facilitate coupling of
multiple ubiquitin units to the protein that is to be degraded. The Saccharomyces cerevisiae
ER-resident E3 ligase Hrd1p/Der3p functions in the metabolically regulated degradation of 3 …
degradation of proteins that are misfolded, that fail to associate with their oligomerization
partners, or whose levels are metabolically regulated. E3 ubiquitin ligases are key enzymes
in the ubiquitination process as they recognize the substrate and facilitate coupling of
multiple ubiquitin units to the protein that is to be degraded. The Saccharomyces cerevisiae
ER-resident E3 ligase Hrd1p/Der3p functions in the metabolically regulated degradation of 3 …