Association between TNF receptors and KIM-1 with kidney outcomes in early-stage diabetic kidney disease
SW Waijer, T Sen, C Arnott, B Neal… - Clinical Journal of the …, 2022 - journals.lww.com
Results In patients with normoalbuminuria (n= 2553), 51 kidney outcomes were recorded
during a median follow-up of 6.1 (interquartile range, 5.8–6.4) years (event rate, 3.5; 95%
confidence interval, 2.6 to 4.6 per 1000 patient-years). Each doubling of baseline TNF
receptor-1 (hazard ratio, 4.2; 95% confidence interval, 1.8 to 9.6) and TNF receptor-2
(hazard ratio, 2.3; 95% confidence interval, 1.5 to 3.6) was associated with a higher risk for
the kidney outcome. Baseline KIM-1, urinary albumin-creatinine ratio, and eGFR were not …
during a median follow-up of 6.1 (interquartile range, 5.8–6.4) years (event rate, 3.5; 95%
confidence interval, 2.6 to 4.6 per 1000 patient-years). Each doubling of baseline TNF
receptor-1 (hazard ratio, 4.2; 95% confidence interval, 1.8 to 9.6) and TNF receptor-2
(hazard ratio, 2.3; 95% confidence interval, 1.5 to 3.6) was associated with a higher risk for
the kidney outcome. Baseline KIM-1, urinary albumin-creatinine ratio, and eGFR were not …
