[HTML][HTML] Hydrogen sulfide inhibits high glucose-induced NADPH oxidase 4 expression and matrix increase by recruiting inducible nitric oxide synthase in kidney …
HJ Lee, DY Lee, MM Mariappan, D Feliers… - Journal of Biological …, 2017 - ASBMB
High-glucose increases NADPH oxidase 4 (NOX4) expression, reactive oxygen species
generation, and matrix protein synthesis by inhibiting AMP-activated protein kinase (AMPK)
in renal cells. Because hydrogen sulfide (H 2 S) inhibits high glucose-induced matrix protein
increase by activating AMPK in renal cells, we examined whether H 2 S inhibits high
glucose-induced expression of NOX4 and matrix protein and whether H 2 S and NO
pathways are integrated. High glucose increased NOX4 expression and activity at 24 h in …
generation, and matrix protein synthesis by inhibiting AMP-activated protein kinase (AMPK)
in renal cells. Because hydrogen sulfide (H 2 S) inhibits high glucose-induced matrix protein
increase by activating AMPK in renal cells, we examined whether H 2 S inhibits high
glucose-induced expression of NOX4 and matrix protein and whether H 2 S and NO
pathways are integrated. High glucose increased NOX4 expression and activity at 24 h in …