Intracellular chloride and scaffold protein Mo25 cooperatively regulate transepithelial ion transport through WNK signaling in the malpighian tubule
Q Sun, Y Wu, S Jonusaite, JM Pleinis… - Journal of the …, 2018 - journals.lww.com
Background With No Lysine kinase (WNK) signaling regulates mammalian renal epithelial
ion transport to maintain electrolyte and BP homeostasis. Our previous studies showed a
conserved role for WNK in the regulation of transepithelial ion transport in the Drosophila
Malpighian tubule. Methods Using in vitro assays and transgenic Drosophila lines, we
examined two potential WNK regulators, chloride ion and the scaffold protein mouse protein
25 (Mo25), in the stimulation of transepithelial ion flux.
ion transport to maintain electrolyte and BP homeostasis. Our previous studies showed a
conserved role for WNK in the regulation of transepithelial ion transport in the Drosophila
Malpighian tubule. Methods Using in vitro assays and transgenic Drosophila lines, we
examined two potential WNK regulators, chloride ion and the scaffold protein mouse protein
25 (Mo25), in the stimulation of transepithelial ion flux.