[HTML][HTML] The endoplasmic reticulum–resident E3 ubiquitin ligase Hrd1 controls a critical checkpoint in B cell development in mice
Humoral immunity involves multiple checkpoints that occur in B cell development,
maturation, and activation. The pre–B-cell receptor (pre-BCR) is expressed following the
productive recombination of the immunoglobulin heavy-chain gene, and sSignalsing
through the pre-BCR are required for the differentiation of pre–B cells into immature B cells.
However, the molecular mechanisms controlling the pre-BCR expression and signaling
strength remain undefined. Herein, we probed the role of the endoplasmic reticulum …
maturation, and activation. The pre–B-cell receptor (pre-BCR) is expressed following the
productive recombination of the immunoglobulin heavy-chain gene, and sSignalsing
through the pre-BCR are required for the differentiation of pre–B cells into immature B cells.
However, the molecular mechanisms controlling the pre-BCR expression and signaling
strength remain undefined. Herein, we probed the role of the endoplasmic reticulum …