Negative regulation of T-cell function by PD-1
Y yuan Zha, C Blank… - Critical Reviews™ in …, 2004 - dl.begellhouse.com
Y yuan Zha, C Blank, TF Gajewski
Critical Reviews™ in Immunology, 2004•dl.begellhouse.comABSTRACT PD-1 is a receptor inducibly expressed on CD4+ and CD8+ T cells Mowing
activation. PD-1-deficient mice develop signs of autoimmunity, suggesting a negative
regulatory role for PD-1 in dampening lymphocyte responses. The expression of one ligand
for PD-1, designated PD-L1 or B7-H1, on tumor cells of a variety of histologies has
suggested a potential mechanism for tumor escape from immune destruction. This review
summarizes data regarding PD-1 and related negative regulatory receptors, focusing on …
activation. PD-1-deficient mice develop signs of autoimmunity, suggesting a negative
regulatory role for PD-1 in dampening lymphocyte responses. The expression of one ligand
for PD-1, designated PD-L1 or B7-H1, on tumor cells of a variety of histologies has
suggested a potential mechanism for tumor escape from immune destruction. This review
summarizes data regarding PD-1 and related negative regulatory receptors, focusing on …
Abstract
PD-1 is a receptor inducibly expressed on CD4+ and CD8+ T cells Mowing activation. PD-1-deficient mice develop signs of autoimmunity, suggesting a negative regulatory role for PD-1 in dampening lymphocyte responses. The expression of one ligand for PD-1, designated PD-L1 or B7-H1, on tumor cells of a variety of histologies has suggested a potential mechanism for tumor escape from immune destruction. This review summarizes data regarding PD-1 and related negative regulatory receptors, focusing on implications for potentiating antitumor immunity in vivo.
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