Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis
S Gaul, A Leszczynska, F Alegre, B Kaufmann… - Journal of …, 2021 - Elsevier
Background & Aims Increased hepatocyte death contributes to the pathology of acute and
chronic liver diseases. However, the role of hepatocyte pyroptosis and extracellular
inflammasome release in liver disease is unknown. Methods We used primary mouse and
human hepatocytes, hepatocyte-specific leucine 351 to proline Nlrp3 KI CreA mice, and
Gsdmd KO mice to investigate pyroptotic cell death in hepatocytes and its impact on liver
inflammation and damage. Extracellular NOD-, LRR-, and pyrin domain-containing protein 3 …
chronic liver diseases. However, the role of hepatocyte pyroptosis and extracellular
inflammasome release in liver disease is unknown. Methods We used primary mouse and
human hepatocytes, hepatocyte-specific leucine 351 to proline Nlrp3 KI CreA mice, and
Gsdmd KO mice to investigate pyroptotic cell death in hepatocytes and its impact on liver
inflammation and damage. Extracellular NOD-, LRR-, and pyrin domain-containing protein 3 …