Targeting the inflammasome in cardiovascular disease
MB Olsen, I Gregersen, Ø Sandanger, K Yang… - Basic to Translational …, 2022 - jacc.org
MB Olsen, I Gregersen, Ø Sandanger, K Yang, M Sokolova, BE Halvorsen, L Gullestad…
Basic to Translational Science, 2022•jacc.orgThe pathogenesis of cardiovascular disease (CVD) is complex and multifactorial, and
inflammation plays a central role. Inflammasomes are multimeric protein complexes that are
activated in a 2-step manner in response to infection or tissue damage. Upon activation the
proinflammatory cytokines, interleukins-1β and-18 are released. In the last decade, the
evidence that inflammasome activation plays an important role in CVD development
became stronger. We discuss the role of different inflammasomes in the pathogenesis of …
inflammation plays a central role. Inflammasomes are multimeric protein complexes that are
activated in a 2-step manner in response to infection or tissue damage. Upon activation the
proinflammatory cytokines, interleukins-1β and-18 are released. In the last decade, the
evidence that inflammasome activation plays an important role in CVD development
became stronger. We discuss the role of different inflammasomes in the pathogenesis of …
Summary
The pathogenesis of cardiovascular disease (CVD) is complex and multifactorial, and inflammation plays a central role. Inflammasomes are multimeric protein complexes that are activated in a 2-step manner in response to infection or tissue damage. Upon activation the proinflammatory cytokines, interleukins-1β and -18 are released. In the last decade, the evidence that inflammasome activation plays an important role in CVD development became stronger. We discuss the role of different inflammasomes in the pathogenesis of CVD, focusing on atherosclerosis and heart failure. This review also provides an overview of existing experimental studies and clinical trials on inflammasome inhibition as a therapeutic target in these disorders.
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