Compared with males, females have lower BP before age 60, blunted hypertensive
response to angiotensin II, and a leftward shift in pressure natriuresis. This study tested the
concept that this female advantage associates with a distinct sexual dimorphic pattern of
transporters along the nephron. We applied quantitative immunoblotting to generate profiles
of transporters, channels, claudins, and selected regulators in both sexes and assessed the
physiologic consequences of the differences. In rats, females excreted a saline load more …