Moving toward a common pathogenic mechanism and therapeutic targets for APOL1 nephropathies
LA Bruggeman, T Azhibekov, JF O'Toole - American Journal of Kidney …, 2022 - ajkd.org
Polymorphisms in the gene for apolipoprotein L1 (APOL1) contribute significant risk to
several forms of nondiabetic kidney disease, including focal segmental glomerulosclerosis
(FSGS), severe lupus nephritis, hypertension-attributed chronic kidney disease (CKD), and
HIV-associated nephropathy. The complete pathogenic mechanism behind these APOL1
nephropathies remains unclear, although several pathogenic effects have been ascribed to
APOL1 variants, involving the role of interferons, intracellular ion fluxes, mitochondrial injury …
several forms of nondiabetic kidney disease, including focal segmental glomerulosclerosis
(FSGS), severe lupus nephritis, hypertension-attributed chronic kidney disease (CKD), and
HIV-associated nephropathy. The complete pathogenic mechanism behind these APOL1
nephropathies remains unclear, although several pathogenic effects have been ascribed to
APOL1 variants, involving the role of interferons, intracellular ion fluxes, mitochondrial injury …