APOL1 kidney disease risk variants: an evolving landscape
PD Dummer, S Limou, AZ Rosenberg, J Heymann… - Seminars in …, 2015 - Elsevier
Summary Apolipoprotein L1 (APOL1) genetic variants account for much of the excess risk of
chronic and end-stage kidney disease, which results in a significant global health disparity
for persons of African ancestry. We estimate the lifetime risk of kidney disease in APOL1
dual-risk allele individuals to be at least 15%. Experimental evidence suggests a direct role
of APOL1 in pore formation, cellular injury, and programmed cell death in renal injury. The
APOL1 BH3 motif, often associated with cell death, is unlikely to play a role in APOL1 …
chronic and end-stage kidney disease, which results in a significant global health disparity
for persons of African ancestry. We estimate the lifetime risk of kidney disease in APOL1
dual-risk allele individuals to be at least 15%. Experimental evidence suggests a direct role
of APOL1 in pore formation, cellular injury, and programmed cell death in renal injury. The
APOL1 BH3 motif, often associated with cell death, is unlikely to play a role in APOL1 …