Intracellular APOL1 risk variants cause cytotoxicity accompanied by energy depletion
D Granado, D Müller, V Krausel… - Journal of the …, 2017 - journals.lww.com
Population genetic approaches have uncovered a strong association between kidney
diseases and two sequence variants of the APOL1 gene, called APOL1 risk variant G1 and
variant G2, compared with the nonrisk G0 allele. However, the mechanism whereby these
variants lead to disease manifestation and, in particular, whether this involves an
intracellular or extracellular pool of APOL1 remains unclear. Herein, we show a
predominantly intracellular localization of APOL1 G0 and the renal risk variants, which …
diseases and two sequence variants of the APOL1 gene, called APOL1 risk variant G1 and
variant G2, compared with the nonrisk G0 allele. However, the mechanism whereby these
variants lead to disease manifestation and, in particular, whether this involves an
intracellular or extracellular pool of APOL1 remains unclear. Herein, we show a
predominantly intracellular localization of APOL1 G0 and the renal risk variants, which …