[HTML][HTML] Apolipoprotein L1 confers pH-switchable ion permeability to phospholipid vesicles
J Bruno, N Pozzi, J Oliva, JC Edwards - Journal of Biological Chemistry, 2017 - ASBMB
Apolipoprotein L1 (ApoL1) is a human serum protein conferring resistance to African
trypanosomes, and certain ApoL1 variants increase susceptibility to some progressive
kidney diseases. ApoL1 has been hypothesized to function like a pore-forming colicin and
has been reported to have permeability effects on both intracellular and plasma membranes.
Here, to gain insight into how ApoL1 may function in vivo, we used vesicle-based ion
permeability, direct membrane association, and intrinsic fluorescence to study the activities …
trypanosomes, and certain ApoL1 variants increase susceptibility to some progressive
kidney diseases. ApoL1 has been hypothesized to function like a pore-forming colicin and
has been reported to have permeability effects on both intracellular and plasma membranes.
Here, to gain insight into how ApoL1 may function in vivo, we used vesicle-based ion
permeability, direct membrane association, and intrinsic fluorescence to study the activities …