Renal transplantation is the preferred treatment of ESKD, but the shortage of suitable donor
kidneys from the cadaver pool means that many patients with ESKD will not receive a kidney
transplant. Xenotransplantation has long represented a solution to the kidney shortage, but
the occurrence of antibody-mediated rejection has precluded its clinical development.
Developments in somatic cell nuclear transfer in pigs and gene editing tools have led to the
creation of new donor pigs with greatly improved crossmatches to patients. In addition …